翻訳と辞書 Words near each other ・ Tubular Bells 2003 ・ Tubular Bells for Two ・ Tuberorachidion pumilio ・ Tuberoschistura ・ Tuberoschistura baenzigeri ・ Tuberositas Tibiae Advancement (TTA) technique ・ Tuberosity of the tibia ・ Tuberosity of the ulna ・ Tuberostylis ・ Tuberothelais flavolineata ・ Tuberous breasts ・ Tuberous morning glory ・ Tuberous receptor ・ Tuberous sclerosis ・ Tuberous sclerosis complex tumor suppressors ・ Tuberous sclerosis protein ・ Tuberozygocera albostictica ・ Tubersent ・ Tuberville ・ Tuberville v Savage ・ Tubes and primers for ammunition ・ Tubestart ・ Tubestock ・ Tubeteika ・ TubeTwist ・ Tubeufia ・ Tubeufia pezizula ・ Tubeufiaceae ・ Tubeway (video game) ・ Tubeway Army Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Tuberous sclerosis protein ： ウィキペディア英語版 Tuberous sclerosis protein Tuberous sclerosis proteins 1 and 2, also known as TSC1 (hamartin) and TSC2 (tuberin), form a protein-complex. The encoding two genes are ''TSC1'' and ''TSC2''. The complex is known as a tumor suppressor. Mutations in these genes can cause tuberous sclerosis complex. Depending on the grade of the disease, mental retardation, epilepsy and tumors of the skin, retina, heart, kidney and the central nervous system can be symptoms. == Physiological roles == The TSC1/TSC2-complex integrates environmental signals such as stress and energy status in yeast and stress, energy status and growth factors in mammals into TOR signalling. In the case of stress (DNA damage, hypoxia) or low energy availability, it is activated and regulates protein synthesis down. Growth factors lead to an inhibition of the complex and have a positive effect on protein synthesis. Defects in its genes result in less control of cell growth and may cause tuberous sclerosis or tuberous sclerosis complex (TSC). TSC is a rare genetic disease causing benign tumours to grow in the brain and on other vital organs. A combination of symptoms may include seizures, developmental delay, behavioural problems, skin abnormalities, lung and kidney disease. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Tuberous sclerosis protein」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.